Glucagon-Like Peptide-1 Protects Against Cardiac Microvascular Injury in Diabetes via a cAMP/PKA/Rho-Dependent Mechanism

@inproceedings{Wang2013GlucagonLikePP,
  title={Glucagon-Like Peptide-1 Protects Against Cardiac Microvascular Injury in Diabetes via a cAMP/PKA/Rho-Dependent Mechanism},
  author={Dongjuan Wang and Peng Luo and Yabin Wang and Wei-jie Li and Chen Wang and Dongdong Sun and Rongqing Zhang and Tao Su and Xiaowei Ma and Chao Zeng and Haichang Wang and Jun Ren and Feng Cao},
  booktitle={Diabetes},
  year={2013}
}
Impaired cardiac microvascular function contributes to cardiovascular complications in diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential cardioprotective properties in addition to its glucose-lowering effect. This study was designed to evaluate the impact of GLP-1 on cardiac microvascular injury in diabetes and the underlying mechanism involved. Experimental diabetes was induced using streptozotocin in rats. Cohorts of diabetic rats received a 12-week treatment of vildagliptin… CONTINUE READING
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