Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop

@inproceedings{Cornu2009GlucagonLikePP,
  title={Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop},
  author={Marion Cornu and J Y Yang and Evrim Jaccard and Carine Poussin and Christian Widmann and Bernard Thorens},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE The gluco-incretin hormones glucagon-like peptide (GLP)-1 and gastric inhibitory peptide (GIP) protect beta-cells against cytokine-induced apoptosis. Their action is initiated by binding to specific receptors that activate the cAMP signaling pathway, but the downstream events are not fully elucidated. Here we searched for mechanisms that may… CONTINUE READING