Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

@inproceedings{Cunha2009GlucagonLikePA,
  title={Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB},
  author={Daniel Andrade Cunha and Laurence Ladri{\`e}re and Fernanda Ortis and Mariana Igoillo-Esteve and Esteban N Gurzov and R. Miguel Lupi and Piero Marchetti and Decio L. Eizirik and Miriam Cnop},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Chronic exposure of pancreatic beta-cells to saturated free fatty acids (FFAs) causes endoplasmic reticulum (ER) stress and apoptosis and may contribute to beta-cell loss in type 2 diabetes. Here, we evaluated the molecular mechanisms involved in the protection of beta-cells from lipotoxic ER stress by glucagon-like peptide (GLP)-1 agonists utilized in the treatment of type 2 diabetes. RESEARCH DESIGN AND METHODS INS-1E or fluorescence-activated cell sorter-purified primary rat beta… CONTINUE READING
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