Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

@article{Anesten2019GlucagonLikePB,
  title={Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus},
  author={F. Anesten and D. Mishra and Adri{\`a} Dalmau Gasull and Linda Engstr{\"o}m-Ruud and Jakob Bellman and V. Palsdottir and F. Zhang and S. Trapp and K. Skibicka and M. Poutanen and John-Olov Jansson},
  journal={Neuroendocrinology},
  year={2019},
  volume={109},
  pages={310 - 321}
}
  • F. Anesten, D. Mishra, +8 authors John-Olov Jansson
  • Published 2019
  • Chemistry
  • Neuroendocrinology
  • Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innervate energy balance-regulating areas, such as the external lateral parabrachial nucleus (PBNel); essential for induction of anorexia. Using a validated novel IL-6-reporter mouse… CONTINUE READING
    1 Citations

    Figures and Tables from this paper

    References

    SHOWING 1-10 OF 56 REFERENCES
    Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.
    • 16
    Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
    • 97
    • PDF