Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

  title={Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus},
  author={Fredrik Anesten and Devesh Mishra and Adri{\`a} Dalmau Gasull and Linda Engstr{\"o}m-Ruud and Jakob Bellman and Vilborg Palsdottir and Fuping Zhang and Stefan Trapp and Karolina P. Skibicka and Matti Poutanen and John-Olov Jansson},
  pages={310 - 321}
Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innervate energy balance-regulating areas, such as the external lateral parabrachial nucleus (PBNel); essential for induction of anorexia. Using a validated novel IL-6-reporter mouse… 
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GLP-1 physiology informs the pharmacotherapy of obesity
  • D. Drucker
  • Medicine, Biology
    Molecular metabolism
  • 2021


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