• DOI:10.1159/000499693
Corpus ID: 208014066

Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

@article{Anesten2019GlucagonLikePB,
  title={Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus},
  author={F. Anesten and D. Mishra and Adri{\`a} Dalmau Gasull and Linda Engstr{\"o}m-Ruud and Jakob Bellman and V. Palsdottir and F. Zhang and S. Trapp and K. Skibicka and M. Poutanen and John-Olov Jansson},
  journal={Neuroendocrinology},
  year={2019},
  volume={109},
  pages={310 - 321}
}

F. Anesten, D. Mishra, +8 authors John-Olov Jansson

Published 2019

Chemistry

Neuroendocrinology

Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innervate energy balance-regulating areas, such as the external lateral parabrachial nucleus (PBNel); essential for induction of anorexia. Using a validated novel IL-6-reporter mouse… CONTINUE READING

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