Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus
@article{Anesten2019GlucagonLikePB, title={Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus}, author={F. Anesten and D. Mishra and Adri{\`a} Dalmau Gasull and Linda Engstr{\"o}m-Ruud and Jakob Bellman and V. Palsdottir and F. Zhang and S. Trapp and K. Skibicka and M. Poutanen and John-Olov Jansson}, journal={Neuroendocrinology}, year={2019}, volume={109}, pages={310 - 321} }
Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innervate energy balance-regulating areas, such as the external lateral parabrachial nucleus (PBNel); essential for induction of anorexia. Using a validated novel IL-6-reporter mouse… CONTINUE READING
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Interleukin‐6 in the central amygdala is bioactive and co‐localised with glucagon‐like peptide‐1 receptor
- Chemistry, Medicine
- Journal of neuroendocrinology
- 2019
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