Glucagon-CREB/CRTC2 signaling cascade regulates hepatic BMAL1 protein.

@article{Sun2015GlucagonCREBCRTC2SC,
  title={Glucagon-CREB/CRTC2 signaling cascade regulates hepatic BMAL1 protein.},
  author={Xiujie Sun and Fabin Dang and Deyi Zhang and Yuan Yuan and Cui Zhang and Yuting Wu and Yiguo Wang and Yi Liu},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 4},
  pages={
          2189-97
        }
}
Energy metabolism follows a diurnal pattern responding to the cycles of light and food exposures. Although food availability is a potent synchronizer of peripheral circadian clock in mammals, the underlying mechanism remains elusive. Here, we found that the temporal signals of fasting and refeeding hormones regulate the transcription of Bmal1, a key transcription activator of molecular clock, in the liver. During fasting, glucagon, a major fasting hormone, activates CREB/CRTC2 transcriptional… CONTINUE READING
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