Glucagon: role in the hyperglycemia of diabetes mellitus.

  title={Glucagon: role in the hyperglycemia of diabetes mellitus.},
  author={Rebecca Dobbs and Hiroaki Sakurai and Hiroshi Sasaki and G R Faloona and Isabel Valverde and Danielle Baetens and Lelio Orci and Roger H. Unger},
  volume={187 4176},
Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.