Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro

@article{Kurose1992GlucagonIA,
  title={Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro},
  author={Takeshi Kurose and Kinsuke Tsuda and Hitoshi Ishida and Kuniro Tsuji and Yasuo Okamoto and Yoshiyuki Tsuura and Seika Kato and Masaru Usami and Hiroo Imura and Yutaka Seino},
  journal={Diabetologia},
  year={1992},
  volume={35},
  pages={1035-1041}
}
Changes in glucagon, insulin and somatostatin secretion induced by electrical splanchnic nerve stimulation were examined in rats treated with streptozotocin as neonates and as adults. In order to study the direct neural effects we used the isolated perfused rat pancreas with intact left splanchnic nerve in vitro. In normal rats splanchnic nerve stimulation causes significant decreases in insulin (30–40%) and somatostatin (30–50%) secretion at both 16.7 mmol/l and 1 mmol/l glucose concentrations… CONTINUE READING