GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.

@article{Yang2011GluA4II,
  title={GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.},
  author={Yi-mei Yang and Jamila Aitoubah and Amanda Lauer and Mutsuo Nuriya and Kogo Takamiya and Zhengping Jia and Bradford J. May and Richard L. Huganir and L Y Wang},
  journal={The Journal of physiology},
  year={2011},
  volume={589 17},
  pages={4209-27}
}
Fast excitatory synaptic transmission in central synapses is mediated primarily by AMPA receptors (AMPARs), which are heteromeric assemblies of four subunits, GluA1-4. Among these subunits, rapidly gating GluA3/4 appears to be the most abundantly expressed to enable neurotransmission with submillisecond precision at fast rates in subsets of central synapses. However, neither definitive identification of the molecular substrate for native AMPARs in these neurons, nor their hypothesized… CONTINUE READING

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