Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction.

@article{Thornhill2007GlomerulotubularDI,
  title={Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction.},
  author={Barbara A. Thornhill and Michael S. Forbes and Elizabeth S Marcinko and Robert L. Chevalier},
  journal={Kidney international},
  year={2007},
  volume={72 9},
  pages={1103-12}
}
Ureteropelvic junction obstruction is a common cause of congenital obstructive nephropathy. To study the pathogenesis of nephropathy, a variable-partial, complete or a sham unilateral ureteral obstruction (UUO) was produced in mice within 2 days of birth. The obstruction was released in some animals at 7 days and kidneys harvested at 7-42 days of age for histologic and morphometric study. Renal parenchymal growth was stunted by partial UUO with the impairment proportional to the duration and… CONTINUE READING