Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats.

@article{Slomowitz2002GlomerulotubularBD,
  title={Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats.},
  author={Larry A Slomowitz and Aihua Deng and John S. Hammes and Francis B Gabbai and Scott C. Thomson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2002},
  volume={282 4},
  pages={R1096-103}
}
The glomerular filtration rate (GFR) normally increases during glycine infusion, which is a test of "renal reserve." Renal reserve is absent in diabetes mellitus. GFR increases after protein feeding because of increased tubular reabsorption, which reduces the signal for tubuloglomerular feedback (TGF). Dietary protein restriction normalizes some aspects of glomerular function in diabetes. Renal micropuncture was performed in rats 4-5 wk after diabetes was induced by streptozotocin to determine… CONTINUE READING
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