Glomerulosclerosis and viral gene expression in HIV-transgenic mice: role of nef.

@article{Kajiyama2000GlomerulosclerosisAV,
  title={Glomerulosclerosis and viral gene expression in HIV-transgenic mice: role of nef.},
  author={W Kajiyama and Jeffrey B. Kopp and Nancy J Marinos and Paul E. Klotman and Peter Dickie},
  journal={Kidney international},
  year={2000},
  volume={58 3},
  pages={1148-59}
}
BACKGROUND Human immunodeficiency virus (HIV)-associated nephropathy is characterized by focal segmental glomerulosclerosis and microcystic tubular dilation. We have previously described a mouse transgenic for a Deltagag-pol HIV-1 genome, which develops glomerulosclerosis, cutaneous papillomas, and cataracts. METHODS We developed mice transgenic for a Deltagag-pol-nef HIV genome in order to investigate the role of the nef gene in these phenotypes. RESULTS One transgenic line, X5, expressed… CONTINUE READING

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