Glomerulosclerosis and progression: effect of subantihypertensive doses of alpha and beta blockers.

@article{Amann2001GlomerulosclerosisAP,
  title={Glomerulosclerosis and progression: effect of subantihypertensive doses of alpha and beta blockers.},
  author={Kerstin Amann and Andreas Koch and J{\"u}rgen Hofstetter and Marie Luise Gross and Christian Haas and Stephan Reinhold Orth and Heimo Ehmke and Lars Christian Rump and Eberhard Ritz},
  journal={Kidney international},
  year={2001},
  volume={60 4},
  pages={1309-23}
}
BACKGROUND Uremia is characterized by inadequately increased sympathetic activity. Sympathetic overactivity is involved in the genesis of hypertension in uremia, but its potential role on progression has not been well investigated. To address this issue, the effect of subantihypertensive doses of an alpha blocker and a beta blocker, and their combination on renal morphology and on albuminuria were investigated in the model of the subtotally nephrectomized rat. METHODS Male Sprague-Dawley rats… CONTINUE READING
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