Glomerulopathy induced by graft-versus-host reaction in the rat. Requirement of donor CD4+ T lymphocytes and MHC class II incompatibility at the lymphoid compartment.

@article{Aten1992GlomerulopathyIB,
  title={Glomerulopathy induced by graft-versus-host reaction in the rat. Requirement of donor CD4+ T lymphocytes and MHC class II incompatibility at the lymphoid compartment.},
  author={J. A. Aten and Ren{\'e} J M Stet and Jos{\'e}e P A Wagenaar-Hilbers and Jan J. Weening and Gert Jan J Fleuren and Paul Nieuwenhuis},
  journal={Scandinavian journal of immunology},
  year={1992},
  volume={35 1},
  pages={93-105}
}
Graft-versus-host reactions (GVHR) can be associated with several autoimmune phenomena involving the kidney as a target organ. By transferring lymphocytes of AO rats into complete Freund's adjuvant-pretreated (AO x BN)F1 hybrids, a dose-dependent GVHR with glomerulopathy was experimentally induced. IgM, IgG1, and IgG2a were deposited in the mesangial area… CONTINUE READING