author={W. Couser},
  journal={The Lancet},
Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment
Because CPN is a rodent-specific entity, the finding of a small, statistically significant increase in renal tubule tumors, linked to exacerbation of CPN by a test chemical in a preclinical study for carcinogenicity, can be regarded as having no relevance for extrapolation in human risk assessment. Expand
Typing of the pilus-protein-encoding FCT region and biofilm formation as novel parameters in epidemiological investigations of Streptococcus pyogenes isolates from various infection sites.
No correlation could be established between the anatomical site of isolation and the emm or the FCT type, and there was no relationship between biofilm formation and emm type, antibiotic-resistance or PFGE patterns, but a novel association between bioFilm formation and FCTtype became obvious among strains from the authors' collection. Expand
The association of various HLA-A, -B and -DR loci with membranous glomerulonephritis, IgA nephropathy, and focal segmental glomerulosclerosis in KwaZulu-Natal renal patients.
HLA-B40 and HLA-A33 is a possible disease susceptibility marker for glomerulonephritides in Indians and alleles in linkage might be responsible for the rarity of IgAN in Africans but further studies need to be employed. Expand
Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus
  • R. Bruni, P. Possenti, +5 authors F. Cellesi
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • 2017
The marked efficacy of these drug‐loaded nanocarriers in repairing damaged podocytes may pave the way for developing a cell‐targeted administration of new and traditional drugs, increasing efficacy and limiting side effects. Expand
1 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA, 2 Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital,Expand
Prevalence and antimicrobial susceptibility profiles of bacterial pathogens isolated from outpatients with Upper respiratory tract infections in Kitui District Hospital, Kenya
A thesis submitted in partial fulfillment of the Requirements for the award of the degree of Master of Science (microbiology) in the school of pure and applied Sciences of Kenyatta University. RCExpand
Knowledge Discovery in Spectral Data by Means of Complex Networks
A technique for reconstructing networks from spectral data sets, where nodes represent spectral bins, and pairs of them are connected when their intensities follow a pattern associated with a disease, is defined. Expand
Crescentic Glomerulonephritis and Subepidermal Blisters with Autoantibodies to α5 and α6 Chains of Type IV Collagen
We describe a novel autoimmune disease characterized by severe subepidermal bullous eruption and crescentic glomerulonephritis with autoantibodies directed against the noncollagenous domain of the α5Expand
Cytokine profiles and their relevance to human transplantation
Primary univariate analysis revealed that HLA and HLA-DR mismatching, female donor sex,MLR-stimulated IL-10, MLR- Stimulated IFN-y and spontaneous IL-4 secretion were associated with an increased risk of rejection. Expand