Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer

@article{Goffin2003GlomeruloidMP,
  title={Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer},
  author={John R. Goffin and Oddbj\orn Straume and Pierre O Chappuis and J S Brunet and Louis R{\'e}al B{\'e}gin and Nancy Hamel and Nora Wong and Lars Andreas Akslen and William D Foulkes},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={1031 - 1034}
}
Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2–3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions. 

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The impact of germ-line BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast cancer: 10 year follow up data

  • JR Goffin, PO Chappuis, +5 authors J Boyd
  • Cancer 97:
  • 2003
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