Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells

  title={Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells},
  author={Saburo Kishimoto and Hideya Takenaka and Ryosuke Shibagaki and Y Noda and M. Yamamoto and Hirokazu Yasuno},
  journal={Journal of Cutaneous Pathology},
The case of a Japanese woman with glomeruloid hemangioma, an initial marker for POEMS syndrome, is reported. Her cutaneous lesions were multiple and consisted of glomeruloid hemangiomas, cherry‐type capillary hemangiomas, and a mixture of both. The specimens of glomeruloid hemangiomas were studied by paraffin section immunohistochemistry with a large panel of antibodies and electron microscopy, respectively. The lesions, whose size ranged from minute foci to large nodules, were composed of… 

A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions

This case revealed glomeruloid hemangioma without systemic conditions related to POEMS, and composed of an intravascular proliferation of immature endothelial and pericytic stromal cells.

Uterine Glomeruloid Hemangioma in a Patient Without POEMS Syndrome

It is hypothesized that the glomeruloid endothelial cell proliferation with vascular endothelial growth factor receptor-1 expression may be a paraneoplastic phenomenon and reported what seems to be the first case of visceral glomersuloid hemangioma in a patient without POEMS syndrome.

Paraovarian hemangioma with immunoglobulin deposits in a patient with monoclonal gammopathy of uncertain significance and osteolytic lesions

A case of paraovarian hemangioma is reported in a woman with monoclonal gammopathy of uncertain significance (MGUS) and osteolytic lesions in the skull, who did not show polyneuropathy, cutaneous angiomatoid lesions or other features of POEMS syndrome.

Papillary Hemangiomas and Glomeruloid Hemangiomas Are Distinct Clinicopathological Entities

  • A. Suurmeijer
  • Medicine
    International journal of surgical pathology
  • 2010
Immunostaining for collagen IV staining patterns provide further evidence that papillary and glomeruloid hemangiomas represent distinct histopathological entities and should allow pathologists to readily distinguish between the lesions and make a proper diagnosis.

Glomeruloid hemangioma

A 64‐year‐old Japanese woman suffering from idiopathic thrombocytopenic purpura and Sjögren's syndrome was treated with prednisolone, and the patient was left with minimal residual symptoms.

An unusual presentation of glomeruloid hemangioma in a patient with VHL syndrome: A case report and review of literature

This constitutes the first report of glomeruloid hemangioma in a patient with VHL, and a deletion in the 3p25.3 region was confirmed and no evidence of POEMS syndrome was found in this patient.

Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS

Solitary head and neck GHs in 3 patients, 2 without POEMS, are presented with particular attention to the characteristic EGs, and electron microscopic examination suggested that EGs are enlarged secondary lysosomes (thanatosomes).

Reactive angioendotheliomatosis of the intestine.

A 19-year-old Japanese male with an anal fistula diagnosed endoscopically with Crohn's disease might be a first case of reactive angioendotheliomatosis of the intestine without cutaneous involvement, featuring intravascular proliferation of endothelial cells with histologic resemblance to glomeruloid hemangioma.

Vascular tumors of the skin: a selective review.

While physicians have known about post-mastectomy angiosarcomas from the origin of the radical mastectomy, a new group of unusual vascular proliferations of the mammary skin are being defined, which arise in the setting of breast-conserving surgical treatment with adjuvant radiation therapy.



Glomeruloid Hemangioma A Distinctive Cutaneous Lesion of Multicentric Castleman's Disease Associated with POEMS Syndrome

Because vascular lesions may appear before the full-blown POEMS syndrome develops, it is suggested careful evaluation and follow-up of all patients presenting with glomeruloid hemangioma or cherry-type capillary hemangiological features for potential development of this syndrome.

Glomeruloid hemangioma. A cutaneous marker of POEMS syndrome.

The finding of focal histologic features of tufted angioma (angioblastoma) in the same lesion suggests that a spectrum of hemangiomatous lesions may be seen in POEMS syndrome and glomeruloid hemangioma may represent a reactive endothelial proliferation rather than a neoplastic lesion.

Littoral Cell Angioma: A Novel Splenic Vascular Lesion Demonstrating Histiocytic Differentiation

The morphologic and immunohistochemical findings in this tumor reflect the dual differentiation potential of the reticuloendothelial cells lining the splenic sinus, justifying the term littoral cell angioma, and recognize a distinct entity that is different from other vascular lesions of the spleen, notably angiosarcoma.

Cutaneous angiomas in POEMS syndrome. An ultrastructural and immunohistochemical study.

Cutaneous manifestations of POEMS (polyneuropathy, organomegaly, endocrinopathies, M-protein, and skin changes) syndrome in a 51-year-old white man included two types of hemangiomas, ie, cherry-type and subcutaneous hemang iomas, which merit study since they constitute an easily recognizable marker ofPOEMS syndrome.

The Nature of Hyaline (Eosinophilic) Globules and Vascular Slits of Kaposi's Sarcoma

Ultrastructural studies of Kaposi's sarcoma from skin biopsies of 24 patients with and without AIDS strongly suggested that erythrophagosomes were most likely the hyaline globules (bodies) seen in light microscopy.

Splenic vascular tumors: a histologic, immunophenotypic, and virologic study.

There are distinct immunophenotypic as well as morphologic features of splenic vascular tumors of the spleen, including littoral cell angiomas have a characteristic CD34-/CD68+/CD21+/ CD8- immunophenotype and hamartomas haveA characteristic CD68-/ CD21- /CD21-/ CDs8+ phenotype.

Spindle Cell Hemangioendothelioma: A Low-Grade Angiosarcoma Resembling a Cavernous Hemangioma and Kaposi's Sarcoma

The term “spindle cell hemangioendothelioma” is suggested for this vascular tumor of low-grade malignancy, which combines the features of both a cavernous hemangioma and Kaposi's sarcoma.


Interesting findings of cutaneous hemangiomas of the POEMS syndrome were 1) the intravascular endothelial proliferation not in the preexisting large vessels but in the capillaries composing the tumor and 2) the presence of particles resembling Epstein‐Barr virus and fine filamentous structures in the cytoplasma of theIntravascular cells.

Cutaneous Angioma in Crow‐Fukase Syndrome: The Nature of Globules within the Endothelial Cells

It is considered that the intracytoplasmic globules seen in the endothelial cells of the cutaneous angiomas of the Crow‐Fukase syndrome are phagolysosomes containing glycoprotein.

Skin changes in POEMS syndrome.

The images of skin changes which appeared in a 39-year-old Caucasian male, who has had rapid, progressive appearance of multiple skin angiomas together with dermal fibrosis with sclerodactylia, pleural and myocardial effusions, pyrexia and capillary leak syndrome, are reported.