Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.

@article{Katoh1991GlomerularSS,
  title={Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.},
  author={Takao Katoh and Kenzo Takahashi and J. Capdevila and Armando L Karara and John R Falck and HarryR. Jacobson and Kamal F. Badr},
  journal={The American journal of physiology},
  year={1991},
  volume={261 4 Pt 2},
  pages={
          F578-86
        }
}
Renal glomerular and cortical metabolism of endogenous arachidonic acid by cytochrome P-450 epoxygenase yields 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EET). Using gas chromatography-mass spectrometry, we measured the synthesis of 8,9-EET from an endogenous pool of arachidonic acid in normal rat kidney. The (8S,9R) isomer was favored over the (8R,9S) isomer in a ratio (%) of 59 to 41 in isolated glomeruli and 68 to 32 in cortex tissue. (8S,9R)- but not (8R,9S)-EET elicited dose… CONTINUE READING
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