Glomerular mesangial cell migration in response to platelet-derived growth factor.

@article{Barnes1990GlomerularMC,
  title={Glomerular mesangial cell migration in response to platelet-derived growth factor.},
  author={Jeffery L. Barnes and Karen Hevey},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1990},
  volume={62 3},
  pages={379-82}
}
Platelet-derived growth factor (PDGF) is a potent mitogenic and chemotactic protein for a variety of cell types. Glomerular mesangial cells also respond to PDGF in terms of proliferation, but, to date, have not been examined for migratory behavior in response to a specific growth factor. Here, we examine the ability of isolated rat mesangial cells to migrate toward gradients of purified PDGF. Chemotaxis assays were performed in two-compartment blind well chambers, each compartment separated by… CONTINUE READING

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