Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice (C57BL/6Jdb/db and C57BL/KsJdb/db)

@article{Grtner1978GlomerularHD,
  title={Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice (C57BL/6Jdb/db and C57BL/KsJdb/db)},
  author={Klaus G{\"a}rtner},
  journal={Diabetologia},
  year={1978},
  volume={15},
  pages={59-63}
}
GFR estimated by the total clearence of51Cr-EDTA increases from 41 to 60 ml/min·m2 at the onset and during the development of marked hyperglycaemia and obesity in female diabetic mice (db/db) of the C57BL/6J and the C57BL/KsJ strains (blood sugar rises from 160 to 400 mg/100 ml). GFR decreases slowly in older diabetic mice (>120 days old) approaching the control values (42±7 ml/ min·m2) and then decreases still further. The total clearance of14C-hippuric acid is unaltered indb/db mice and… CONTINUE READING

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