Glomerular filtration rate measurement and estimation in chronic kidney disease

  title={Glomerular filtration rate measurement and estimation in chronic kidney disease},
  author={George J. Schwartz and Susan L. Furth},
  journal={Pediatric Nephrology},
Glomerular filtration rate (GFR) assesses kidney function. GFR is measured by renal clearance techniques; inulin clearance is the gold standard but is not easily measured. Thus, other methods to determine GFR have been utilized. Endogenous creatinine clearance (CrCl) is the most widely used, but creatinine secretion falsely elevates GFR. Cimetidine inhibits creatinine secretion, such that CrCl equals GFR, provided there are no difficulties with bladder emptying. Estimation of GFR from serum… CONTINUE READING
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