Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study.

@article{James2010GlomerularFR,
  title={Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study.},
  author={Matthew T. James and Brenda R. Hemmelgarn and Natasha Wiebe and Neesh Pannu and Braden J. Manns and Scott W. Klarenbach and Marcello Tonelli},
  journal={Lancet},
  year={2010},
  volume={376 9758},
  pages={2096-103}
}
BACKGROUND Low values of estimated glomerular filtration rate (eGFR) predispose to acute kidney injury, and proteinuria is a marker of kidney disease. We aimed to investigate how eGFR and proteinuria jointly modified the risks of acute kidney injury and subsequent adverse clinical outcomes. METHODS We did a cohort study of 920,985 adults residing in Alberta, Canada, between 2002 and 2007. Participants not needing chronic dialysis at baseline and with at least one outpatient measurement of… CONTINUE READING
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