Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery

@article{Foglieni2000GlomerularFI,
  title={Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery},
  author={Chiara Foglieni and Alessandra Bragonzi and Manuela Cortese and Laura Cant{\'u} and A Boletta and I Chiossone and Marco R. Soria and Lucia Monaco},
  journal={Gene Therapy},
  year={2000},
  volume={7},
  pages={279-285}
}
Gene transfer to the kidney can be achieved with various DNA vectors, resulting in transgene expression in glomerular or tubular districts. Controlling transgene destination is desirable for targeting defined renal cells for specific therapeutic purposes. We previously showed that injection of polyplexes into the rat renal artery resulted in transfection of proximal tubular cells. To investigate whether this process involves glomerular filtration of the DNA-containing particles, fluorescent… CONTINUE READING