Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis.

@article{Urushihara2002GlomerularDA,
  title={Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis.},
  author={Maki Urushihara and Shoji Kagami and Takashi Kuhara and Toshiaki Tamaki and Yasuhiro Kuroda},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2002},
  volume={17 7},
  pages={1189-96}
}
BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the development of glomerular injury in rat experimental glomerulonephritis (GN). However, the significance of MMPs in human GN remains obscure. In order to evaluate the role of MMPs in human GN, we examined the glomerular distribution and gelatinolytic activities of MMP-2 and MMP-9 in human GN. METHODS We performed immunohistochemistry with polyclonal anti-MMP-2 and MMP-9 antibodies, and analysed gelatin zymograms of five… CONTINUE READING

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