Glomerular diseases: membranous nephropathy--a modern view.

  title={Glomerular diseases: membranous nephropathy--a modern view.},
  author={Claudio Ponticelli and Richard J. Glassock},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  volume={9 3},
Membranous nephropathy (MN) is an autoimmune disease usually associated with a nephrotic syndrome and it may progress to ESRD in the long term. Its etiology is often unknown (idiopathic MN), whereas other cases have a recognizable etiology (secondary MN). In idiopathic MN, the glomerular lesions are mainly caused by autoantibodies against a podocyte membrane protein, the M-type of phospholipase A2 receptor 1. The natural course of idiopathic MN is quite varied with spontaneous complete or… CONTINUE READING