Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model.

@article{Floege1992GlomerularCE,
  title={Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model.},
  author={Juergen Floege and Charles E. Alpers and Mark W. Burns and P M Pritzl and Kereen B Gordon and William G. Couser and Richard J Johnson},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={66 4},
  pages={485-97}
}
Expansion of the mesangial extracellular matrix (ECM) with subsequent glomerular sclerosis is a prominent finding in most progressive renal diseases. To investigate the chronology of accumulation of ECM components as it relates to previously described cellular events, biopsies were obtained from rats at various times following 5/6-nephrectomy as well as from sham-operated controls. The biopsies were stained with PAS as well as immunostained for PCNA (a cell proliferation marker), monocytes… CONTINUE READING

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