Glomerular basement membrane: in vitro studies of water and protein permeability.

  title={Glomerular basement membrane: in vitro studies of water and protein permeability.},
  author={Barbara Daniels and E Bryan Hauser and William M. Deen and Thomas H. Hostetter},
  journal={The American journal of physiology},
  volume={262 6 Pt 2},
The glomerular basement membrane (GBM) is an integral structural component of the glomerular filter, but its contribution to the hydraulic and macromolecular permeability properties of the glomerulus has been the subject of much controversy. We have modified previously reported methods to develop a technique with which to study filtration properties of microgram quantities of isolated GBM in vitro at physiological pressures. Rat glomeruli were sieved, and cells were removed with N… CONTINUE READING
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