Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways

@article{Ohashi2010GlomerularAI,
  title={Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species—ERK/JNK pathways},
  author={Naro Ohashi and Maki Urushihara and Ryousuke Satou and Hiroyuki Kobori},
  journal={Hypertension Research},
  year={2010},
  volume={33},
  pages={1174-1181}
}
Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pathological conditions. However, there is no detailed information regarding the mechanism of the induced glomerular angiotensinogen. We used genetic pairs of Zucker diabetic fatty (ZDF) obese and lean rats to determine glomerular angiotensinogen expression. The levels of glomerular… CONTINUE READING

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