Glomerular and tubular damage in normotensive and hypertensive rats.

@article{Ofstad2005GlomerularAT,
  title={Glomerular and tubular damage in normotensive and hypertensive rats.},
  author={Jarle Ofstad and Bjarne Magnus Iversen},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={288 4},
  pages={
          F665-72
        }
}
  • J. Ofstad, B. Iversen
  • Published 1 April 2005
  • Medicine, Biology
  • American journal of physiology. Renal physiology
Tubular cell damage is an important mediator of interstitial fibrosis in chronic renal diseases. Glomerular and tubular damage in genetic hypertension was therefore studied. Tubular and glomerular damage was investigated in 10-, 40-, and 70-wk-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and compared with glomerular capillary pressure (P(GC)) and glomerulosclerosis in superficial (OC) and juxtamedullary (JMC). Tubular vimentin was used as criterion of tubular damage… 
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49 Citations

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Citation Type

Development of structural kidney damage in spontaneously hypertensive rats
TLDR
It is argued that hypertensive damage in the SHR is pressure-dependent and it is shown how initial vascular damage leads to a loss of autoregulation and arterial hypertrophy in the juxtamedullary cortex while the outer cortical structures are relatively protected.
Renal Thrombotic Microangiopathy in a Genetic Model of Hypertension in Mice
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These studies characterize vascular and glomerular lesions in R+/A+ mice fed high salt, L-NAME, or both high salt and L- NAME, and provide a murine model of malignant hypertension with renal thrombotic microangiopathy.
Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension
TLDR
It is suggested that ivabradine may be renoprotective in hypertensive kidney disease.
Rosuvastatin beneficially alters the glomerular structure of kidneys from spontaneously hypertensive rats (SHRs)
TLDR
It is hypothesized that renal pleiotropic effect of rosuvastatin can be a therapeutic tool for improving kidney ultrastructure and, consequently, renal function in hypertensive individuals.
Urinary protein excretion in evaluation of renal impairment progression in hypertension
TLDR
Measurement of total urinary protein seems to be of lesser diagnostic and prognostic significance than the evaluation of individual proteins in relation to renal impairment in course of arterial hypertension.
Vascular Hyperactivity in the Rat Renal Aorta Participates in the Association between Immune Complex-Mediated Glomerulonephritis and Systemic Hypertension
TLDR
Alterations of the vascular reactivity are mediated by the endothelium in the renal aorta and plays a determinant role in the production of vasoactive substances such as NO during this process.
D-α-tocopherol reduces renal damage in hypertensive rats
TLDR
It is suggested that D-α-tocopherol supplementation can reduce kidney damage induced by hypertension, and reduced the excretion of thiobarbituric acid-reactive substances (TBARS) in SHR.
Motility of the ureter of the spontaneously hypertensive rat
TLDR
Ureteral dysfunction may be a contributory causative factor in the aetiology of the hypertensive disease process and is tested for in the spontaneously hypertensive rat.
Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage
TLDR
Although transient spironolactone treatment leads to prolonged blood pressure reduction and reduced collagen deposition, long-term organ protection only partially exists, and transient sp ironolact one treatment is less effective than transient losartan treatment.
Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria.
TLDR
A key role for oxidative stress and inflammation in causing systemic and glomerular hypertension and proteinuria is demonstrated in this model of nephrotic syndrome and may have a key role in accelerating renal injury associated with intense proteinuria.
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