Glomerular T cells in Heymann nephritis.

  title={Glomerular T cells in Heymann nephritis.},
  author={Giles Walters and Han-jiang Wu and John F. Knight},
  journal={Clinical and experimental immunology},
  volume={126 2},
Active Heymann nephritis (HN) is a rat model of human membranous nephropathy. The appearance of T cells within the glomeruli of HN rats suggests a role for these cells in the pathogenesis of the disease. The aims of this study were to investigate T cells infiltrating the glomerulus in HN in Lewis rats by polymerase chain reaction (PCR) of their Vbeta chains, CDR3 spectratyping and sequencing. HN was induced in Lewis rats by immunization with renal tubular antigen (Fx1A) in CFA. Kidneys were… CONTINUE READING