Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

@inproceedings{Qi2017GlomerularEM,
  title={Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility},
  author={Haiying Qi and Gabriella A Casalena and Shaolin Shi and Liping Yu and Kerstin Ebefors and Yezhou Sun and Weijia Zhang and Vivette D. D’Agati and Detlef O Schlondorff and B{\"o}rje S Haraldsson and Erwin P. B{\"o}ttinger and Ilse Daehn},
  booktitle={Diabetes},
  year={2017}
}
The molecular signaling mechanisms between glomerular cell types during initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We compared the early transcriptome profile between DKD-resistant C57BL/6J and DKD-susceptible DBA/2J (D2) glomeruli and demonstrated a significant downregulation of essential mitochondrial genes in glomeruli from diabetic D2 mice, but not in C57BL/6J, with comparable hyperglycemia. Diabetic D2 mice manifested increased mitochondrial DNA… CONTINUE READING
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