Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.

@article{Rajput2008GlobusPD,
  title={Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.},
  author={A H Rajput and Harald H. Sitte and A Rajput and Mark E Fenton and Christian Pifl and O Hornykiewicz},
  journal={Neurology},
  year={2008},
  volume={70 16 Pt 2},
  pages={1403-10}
}
BACKGROUND Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains. METHODS Globus pallidus and striatum dopamine (DA) levels were measured with high performance liquid chromatography in eight autopsy confirmed PD and… CONTINUE READING