Globus pallidus deep brain stimulation in dystonia

  title={Globus pallidus deep brain stimulation in dystonia},
  author={Alan L Diamond and Joohi Shahed and Shaheda N Azher and Kevin Dat-Vuong and Joseph Jankovic},
  journal={Movement Disorders},
Globus pallidus deep brain stimulation (GPi‐DBS) is a useful alternative in the treatment of dystonia. Patients selected for GPi‐DBS were prospectively rated with the Unified Dystonia Rating Scale (UDRS). Also, “blinded” videotape assessments were performed. Eleven patients were identified. Compared with pre‐DBS scores, there were improvements in mean total UDRS score (15.3%) and in the following subscores: neck (18.18%), trunk (32.9%), arm(17.9%), and leg (19.9%). One patient developed a skin… 
Treatment of dystonia with deep brain stimulation
Deep brain stimulation for dystonia.
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  • H. Capelle, J. Krauss
  • Medicine
    Neuromodulation : journal of the International Neuromodulation Society
  • 2009
An account on the development of surgical neuromodulation therapy for dystonia, surgical approaches, hardware‐related problems, DBS programming and patient management, and clinical outcome, and the implications of intra‐operative microelectrode recordings and pallidal field potentials for the pathophysiology of dySTONia are discussed.
Neuromodulation for dystonia: target and patient selection.
Deep brain stimulation for dystonia
This review is intended to provide a comprehensive review of the use of DBS for dystonia, focusing mainly on the surgical aspects, clinical outcome, MRI findings and side effects ofDBS.
Deep-brain stimulation for dystonia: current indications and future orientations
The aim of this review is to cover the different aspects of deep-brain stimulation of the internal globus pallidus for dystonia and give an overview of the current indications and future orientations.
Deep brain stimulation for dystonia
A literature analysis on DBS for dystonia is performed and the main results and limits for each subgroup of patients that may help in the selection of dystonic patients who will benefit from DBS are discussed.
Predictive factors of outcome in cervical dystonia following deep brain stimulation: an individual patient data meta-analysis
This individual patient data meta-analysis compared the efficacy of DBS in the globus pallidus internus (GPi) versus subthalamic nucleus (STN) and identified possible predictive factors for CD to provide a common great improvement in the symptoms of CD patients in 3 years.
Rechargeable or Nonrechargeable Deep Brain Stimulation in Dystonia: A Cost Analysis
A cost analysis is performed to compare a rechargeable DBS system, Activa®RC, with nonrechargeable systems, from the perspective of the French public health insurer.


Risperidone-responsive segmental dystonia and pallidal deep brain stimulation
A 67-year-old man with risperidone-responsive segmental dystonia underwent bilateral deep brain stimulation (DBS) of the globus pallidus internus and the Burke–Fahn–Marsden Dystonia Rating Scale was assessed.
Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia.
These findings support the efficacy and safety of the use of bilateral stimulation of the internal globus pallidus in selected patients with primary generalized dystonia.
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It is concluded that pallidotomy is a safe and effective treatment in medically refractory cases of generalized dystonia.
Deep brain stimulation for cervical dystonia
  • J. Krauss
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 2003
I read with interest the recent case report by Chang and colleagues on unilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) in a patient with delayed-onset posttraumatic cervical dystonia, and report that during chronic stimulation the patient’s cervical dySTONia improved, and that he could turn his head to the midline easier than preoperatively.
Deep brain stimulation for dystonia confirming a somatotopic organization in the globus pallidus internus.
The goal of this study was to examine the positions of specific electrode contacts according to patients' clinical evolution, so that a somatotopic organization within the globus pallidus internus could be defined.
Pallidal and thalamic neurostimulation in severe tardive dystonia
A 70 year old woman presented with a 6 year history of medically refractory severe tardive dystonia. After informed consent, a bilateral stereotactic electrode placement targeting the ventral
Electrical stimulation of the globus pallidus internus in patients with primary generalized dystonia: long-term results.
Electrical stimulation of the GPi is an effective, reversible, and adaptable treatment for PGD and should be considered for conditions refractory to pharmaceutical therapies.
Chronic high‐frequency globus pallidus internus stimulation in different types of dystonia: A clinical, video, and MRI report of six patients presenting with segmental, cervical, and generalized dystonia
It is concluded that chronic high‐frequency Gpi stimulation in different types of dystonia is a very effective and safe treatment.
Bilateral pallidal stimulation for blepharospasm–oromandibular dystonia (Meige syndrome)
Long-term follow-up of chronic pallidal DBS in blepharospasm–oromandibular dystonia (Meige syndrome) is presented and a gradual loss of efficacy was noted.
Neurostimulation of the ventral intermediate thalamic nucleus in inherited myoclonus‐dystonia Syndrome
Postoperatively, the patient improved by approximately 80% on the modified version of a myoclonus score without any significant change in the dystonic symptoms, suggesting that neurostimulation of the VIM may be an effective treatment for myOClonus in pharmacologically intractable IMDS.