Globular domain of basement membrane collagen induces autoimmune pulmonary lesions in mice resembling human Goodpasture disease.

@article{Wick1986GlobularDO,
  title={Globular domain of basement membrane collagen induces autoimmune pulmonary lesions in mice resembling human Goodpasture disease.},
  author={Georg Wick and Helga von der Mark and Hartmut Dietrich and Rupert Timpl},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1986},
  volume={55 3},
  pages={308-17}
}
A distinct circulating antibody response could be evoked in C57BL mice after immunization with the globular domain NC1 of basement membrane collagen IV obtained from the mouse Engelbreth-Holm-Swarm tumor when injected together with complete Freund's adjuvant. The antibodies reacted with various subunits of NC1, did not cross-react with other basement membrane proteins, and exhibited a tissue reactivity restricted to certain basement membranes. Tissue-bound antibodies could be detected by direct… CONTINUE READING
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