Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect.

@article{Lingwood2010GlobotriaosylCR,
  title={Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect.},
  author={Clifford Lingwood and Beth A Binnington and Adam Manis and Donald R Branch},
  journal={FEBS letters},
  year={2010},
  volume={584 9},
  pages={1879-86}
}
The glycosphingolipid globotriaosyl ceramide, (Galalpha1-4Galss1-4 glucosyl ceramide-Gb(3)) also known as CD77 and the P(k) blood group antigen, is bound by both verotoxins and by the HIV adhesin, gp120. Gb(3) plays an important receptor role in VT induced hemolytic uremic syndrome (HUS) and HIV infection. The organization of glycolipids, including Gb(3), into lipid rafts is central to both pathologies. The fatty acid heterogeneity within the Gb(3) lipid moiety plays a central role in assembly… CONTINUE READING

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