Globoid cell leukodystrophy in cairn and West Highland white terriers.

@article{Wenger1999GloboidCL,
  title={Globoid cell leukodystrophy in cairn and West Highland white terriers.},
  author={David A Wenger and T Victoria and Muhammed Aboobacker Rafi and Paola Luzi and Marie Th{\'e}r{\`e}se Vanier and Charles H. Vite and Donald F. Patterson and Matthew Haskins},
  journal={The Journal of heredity},
  year={1999},
  volume={90 1},
  pages={
          138-42
        }
}
Krabbe disease or globoid cell leukodystrophy (GLD) is an autosomal recessive disorder resulting from the defective lysosomal hydrolysis of specific galactolipids found primarily in myelin. This leads to severe neurological symptoms including seizures, hypotonia, blindness, and death, usually before 2 years of age in human patients. In addition to human patients, several animals, including dog, mouse, and monkey, have the same disease caused by a deficiency of galactocerebrosidase (GALC… 

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