Globoid Cell Leucodystrophy in Polled Dorset Sheep

@article{Pritchard1980GloboidCL,
  title={Globoid Cell Leucodystrophy in Polled Dorset Sheep},
  author={David Pritchard and D. V. Napthine and A. J. Sinclair},
  journal={Veterinary Pathology},
  year={1980},
  volume={17},
  pages={399 - 405}
}
Globoid cell leucodystrophy (Krabbe's disease) was diagnosed in two Polled Dorset sheep from a stud farm. Clinical signs were hind limb incoordination progressing to tetraplegia. Histologic changes in white matter of the brain were myelin destruction, loss of oligodendroglia, astrogliosis and accumulation of distinctive periodic acid-Schiff (PAS)-positive globoid cells. The activities of galactocerebroside β-galactosidase, the lysosomal enzyme specifically deficient in globoid leucodystrophy… 

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