Globin synthesis in mouse erythroleukemia cells in vitro: a switch in beta chains due to inducing agent

@inproceedings{Alter1977GlobinSI,
  title={Globin synthesis in mouse erythroleukemia cells in vitro: a switch in beta chains due to inducing agent},
  author={Blanche P Alter and Sabra C. Goff},
  year={1977}
}
Friend erythroleukemia cells, originally derived from DBA/2 mice, differentiate when cultured with inducing agents. Studies of the different effects of inducing agents on clone 745 have revealed that both dimethyl sulfoxide (DMSO) and hemin produce benzidine-positive cells. Butyric acid produced mature but benzidine-negative cells in this clone. All agents induced globin synthesis above the 0.1% of protein synthesis found in uninduced cells. DMSO induction stimulated globin synthesis 9%, hemin… CONTINUE READING