Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma

  title={Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma},
  author={Jinmai Jiang and Ana Clara P Azevedo-Pouly and Roxana Simona Redis and Eun Joo Lee and Yuriy Gusev and David Allard and Dhruvitkumar S Sutaria and Mohamed Badawi and Ola A. Elgamal and Megan Lerner and Daniel Brackett and George A. Calin and Thomas D. Schmittgen},
Transcribed ultraconserved regions (T-UCRs) are a class of non-coding RNAs with 100% sequence conservation among human, rat and mouse genomes. T-UCRs are differentially expressed in several cancers, however their expression in pancreatic adenocarcinoma (PDAC) has not been studied. We used a qPCR array to profile all 481 T-UCRs in pancreatic cancer specimens, pancreatic cancer cell lines, during experimental pancreatic desmoplasia and in the pancreases of P48Cre/wt; KrasLSL-G12D/wt mice… CONTINUE READING
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