Globally, unrelated protein sequences appear random

@article{Lavelle2010GloballyUP,
  title={Globally, unrelated protein sequences appear random},
  author={Daniel T. Lavelle and William R. Pearson},
  journal={Bioinformatics},
  year={2010},
  volume={26 3},
  pages={310-8}
}
MOTIVATION To test whether protein folding constraints and secondary structure sequence preferences significantly reduce the space of amino acid words in proteins, we compared the frequencies of four- and five-amino acid word clumps (independent words) in proteins to the frequencies predicted by four random sequence models. RESULTS While the human… CONTINUE READING