Global view of enhancer-promoter interactome in human cells.

@article{He2014GlobalVO,
  title={Global view of enhancer-promoter interactome in human cells.},
  author={Bing He and Changya Chen and Li Min Teng and Kai Leng Tan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 21},
  pages={E2191-9}
}
Enhancer mapping has been greatly facilitated by various genomic marks associated with it. However, little is available in our toolbox to link enhancers with their target promoters, hampering mechanistic understanding of enhancer-promoter (EP) interaction. We develop and characterize multiple genomic features for distinguishing true EP pairs from noninteracting pairs. We integrate these features into a probabilistic predictor for EP interactions. Multiple validation experiments demonstrate a… CONTINUE READING
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Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

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