Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1.

  title={Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo $\beta$-lactamase, MBLAC1.},
  author={Chelsea L Gibson and Simona G. Codreanu and Alexandra C. schrimpe-Rutledge and Cassandra L. Retzlaff and Jane Wright and Douglas P. Mortlock and Stacy D. Sherrod and John A. McLean and Randy D. Blakely},
  journal={Molecular omics},
  volume={14 3},
The C. elegans gene swip-10 encodes an orphan metallo β-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized to the encoded protein's single metallo β-lactamase domain. The substrate for the SWIP-10 protein remains unknown and to date no functional roles have been ascribed to MBLAC1, though we have shown that the… 
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  • Chemistry
    Journal of The American Society for Mass Spectrometry
  • 2019
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