Global transmission of oseltamivir-resistant influenza.

@article{Moscona2009GlobalTO,
  title={Global transmission of oseltamivir-resistant influenza.},
  author={Anne Moscona},
  journal={The New England journal of medicine},
  year={2009},
  volume={360 10},
  pages={
          953-6
        }
}
  • A. Moscona
  • Published 2009
  • Biology, Medicine
  • The New England journal of medicine
This winter, the circulating strain of seasonal influenza A virus (H1N1) is resistant to the neuraminidase inhibitor oseltamivir. Dr. Anne Moscona writes that the surprise element of the circulating resistant virus is its apparently spontaneous emergence since 2007. 
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References

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TLDR
The enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients are reported that explain the molecular basis of resistance and indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivIR. Expand
Medical management of influenza infection.
  • A. Moscona
  • Biology, Medicine
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