Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis

@article{Horzempa2008GlobalTR,
  title={Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis},
  author={Joseph Horzempa and Paul E Carlson and Dawn M. O'Dee and Robert M Q Shanks and Gerard J. Nau},
  journal={BMC Microbiology},
  year={2008},
  volume={8},
  pages={172 - 172}
}
After infecting a mammalian host, the facultative intracellular bacterium, Francisella tularensis, encounters an elevated environmental temperature. We hypothesized that this temperature change may regulate genes essential for infection. Microarray analysis of F. tularensis LVS shifted from 26°C (environmental) to 37°C (mammalian) showed ~11% of this bacterium's genes were differentially-regulated. Importantly, 40% of the protein-coding genes that were induced at 37°C have been previously… CONTINUE READING

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