Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs.

@article{Ahlberg2012GlobalTR,
  title={Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs.},
  author={Viktor Ahlberg and Karin L{\"o}vgren Bengtsson and Per Wallgren and Caroline Fossum},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={38 1},
  pages={17-26}
}
ISCOM vaccines induce a balanced Th1/Th2 response, long-lasting antibody responses and cytotoxic T lymphocytes. The mode of action for the adjuvant component, the ISCOM-Matrix, is known to some extent but questions remain regarding its mechanism of action. The Affymetrix GeneChip® Porcine Genome Array was applied to study the global transcriptional response to ISCOM-Matrix in pigs at the injection site and in the draining lymph node 24h after i.m. injection. Gene enrichment analysis revealed… CONTINUE READING
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