Global transcriptional repression: An initial and essential step for Plasmodium sexual development.

@article{Yuda2015GlobalTR,
  title={Global transcriptional repression: An initial and essential step for Plasmodium sexual development.},
  author={Masao Yuda and Shiroh Iwanaga and Izumi W Kaneko and Tomomi Kato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 41},
  pages={12824-9}
}
Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood-stage parasites that proliferate in the circulation. However, little is known about how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates this transition as a transcriptional repressor. Disruption of AP2-G2 in the rodent malaria parasite Plasmodium berghei did not prevent commitment… CONTINUE READING
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A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

A Sinha
Nature • 2014

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