Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR.

@article{Herring2004GlobalTE,
  title={Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR.},
  author={Christopher D. Herring and Frederick R. Blattner},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 20},
  pages={
          6714-20
        }
}
Expression of an amber suppressor tRNA should result in read-through of the 326 open reading frames (ORFs) that terminate with amber stop codons in the Escherichia coli genome, including six pseudogenes. Abnormal extension of an ORF might alter the activities of the protein and have effects on cellular physiology, while suppression of a pseudogene could lead to a gain of function. We used oligonucleotide microarrays to determine if any effects were apparent at the level of transcription in… CONTINUE READING
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