Global transcriptional analysis of nuclear reprogramming in the transition from MEFs to iPSCs.

@article{Dong2013GlobalTA,
  title={Global transcriptional analysis of nuclear reprogramming in the transition from MEFs to iPSCs.},
  author={Fulu Dong and Zhenwei Song and Jinping Zhang and Youde Lu and Chun-Lei Song and Baochun Jiang and Baole Zhang and Peiqing Cong and Hongyan Sun and Fangxiong Shi and Honglin Liu},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2013},
  volume={18 1},
  pages={42-55}
}
Induced pluripotent stem cells (iPSCs) are flourishing in the investigation of cell reprogramming. However, we still know little about the sequential molecular mechanism during somatic cell reprogramming (SCR). Here, we first observed rapid generation of colonies whereas mouse embryonic fibroblasts (MEFs) were induced by OCT4, SOX2, KLF4 (OSK), and vitamin C for 7 days. The colony's global transcriptional profiles were analyzed using Affymetrix microarray. Microarray data confirmed that SCR was… CONTINUE READING
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