Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin.

@article{Ashish2007GlobalSC,
  title={Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin.},
  author={Ashish and Matthew S. Paine and Paul B Perryman and Lin Yang and Helen L. Yin and Joanna K. Krueger},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 35},
  pages={25884-92}
}
Gelsolin regulates the dynamic assembly and disassembly of the actin-based cytoskeleton in non-muscle cells and clears the circulation of filaments released following cell death. Gelsolin is a six-domain (G1-G6) protein activated by calcium via a multi-step process that involves unfolding from a compact form to a more open form in which the three actin-binding sites (on the G1, G2, and G4 subdomains) become exposed. To follow the global structural changes that accompany calcium activation of… CONTINUE READING

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