Global snapshot of the influence of endocytosis upon EGF receptor signaling output.


Trafficking of activated receptors may dictate the signaling output through the exposure to a changing palette of substrates and effectors. Here, we have used the acute application of a chemical inhibitor of dynamin activity, Dynasore, to inhibit internalization of activated EGF receptors together with quantitative mass spectrometry. This has generated a… (More)
DOI: 10.1021/pr3007304