Global response of Saccharomyces cerevisiae to an alkylating agent.

  title={Global response of Saccharomyces cerevisiae to an alkylating agent.},
  author={Sharon Jelinsky and Leona D. Samson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 4},
DNA chip technology enables simultaneous examination of how approximately 6,200 Saccharomyces cerevisiae gene transcript levels, representing the entire genome, respond to environmental change. By using chips bearing oligonucleotide arrays, we show that, after exposure to the alkylating agent methyl methanesulfonate, approximately 325 gene transcript levels are increased and approximately 76 are decreased. Of the 21 genes that already were known to be induced by a DNA-damaging agent, 18 can be… CONTINUE READING
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